In vitro risk assessment of Padina pavonica (Linnaeus) (Brown algae)

Padina pavonica (Linnaeus) Thivy 1960 is a brown algae that antioxidant, antimicrobial, and anticancer effects generally used in soup, salad, other dishes. However, no studies have been reported on safe consumption humans to date. For this purpose, study was conducted determine the cytotoxic genotoxic of P. lymphocytes cultured from human blood. The water extract added into culture tubes at various concentrations (0.5-1000 ?g/mL). Cytotoxic were determined by MTT assay. Antioxidant/oxidant status evaluated total antioxidant capacity (TAC) oxidative (TOS) assays. Genotoxic investigated sister chromatid exchanges micronucleus Our results showed had effects, even higher concentrations. 1000 ?g/mL concentration caused an increase (P<0.05) TOS levels while significantly reducing cell viability. low (50 100 ?g/mL) increased TAC levels. In conclusion, can be safely consumed with its non-genotoxic properties manner dose-dependent.